NetDocuments Support gets a lot of inquiries on compatibility between the NetDocuments integrations and Microsoft's subscription-based Office 365. The legacy Application Integrations have been tested and are compatible with a local 32-bit version of either Office 2010 or 2013. ndOffice is compatible with 32-bit Office 2010, and both 32-bit and 64-bit Office 2013 and 2016.
Update: On June 15, 2016, NetDocuments announced that it will soon allow users to edit documents online using Microsoft's Office 365 web apps. The feature will be released pending Microsoft's testing and approval. Learn more